Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CCR2 | P41597 | 5/20 | 0.62 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LDHA | P00338 | 2/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30305558 | 1.00 | DAO (0.67) | DAOMCL1ALDH1A1TSHRCCR2 | |
| SCHEMBL16599057 | 0.86 | DAO (0.53) | DAOMCL1ALDH1A1TSHRCCR2 | |
| SCHEMBL4327040 | 0.84 | DAO (0.52) | DAOMCL1ALDH1A1TSHRCCR2 | |
| SCHEMBL2830160 | 0.84 | PLA2G10 (0.54) | DAOMCL1ALDH1A1TSHRCCR2 | |
| SCHEMBL27812794 | 0.83 | LDHA (0.69) | DAOMCL1ALDH1A1TSHRCCR2 | |
| Hydrochloric Acid SCHEMBL27784064 | 0.82 | PLA2G10 (0.53) | DAOMCL1ALDH1A1TSHRCCR2 | |
| SCHEMBL7561 | 0.80 | DAO (1.00) | DAOMCL1ALDH1A1TSHRCCR2 | |
| SCHEMBL3638561 | 0.78 | DAO (0.65) | DAOMCL1ALDH1A1TSHRCCR2 | |
| SCHEMBL2157437 | 0.78 | DAO (0.65) | DAOMCL1ALDH1A1TSHRCCR2 | |
| SCHEMBL117186 | 0.78 | MCL1 (1.00) | DAOMCL1ALDH1A1TSHRCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483366-A | Benzazole compounds and preparation method thereof, pharmaceutical composition and purposes | INST MATERIA MEDICA CAMS | 2019-11-22 | — | — | CN | claimed |
| CN-105658625-B | Indole amide compounds as inhibitors of cellular necrosis | 株式会社LG化学 | 2019-05-03 | — | — | CN | claimed |
| CN-105658625-A | Indole amide compound as inhibitor of necrosis | 株式会社LG生命科学 | 2016-06-08 | — | — | CN | claimed |
| CN-1418089-A | Pharmaceutical composition of glycogen phosphorylase inhibitor | PFIZER PROD INC (US) | 2003-05-14 | — | — | CN | claimed |
| CN-1098838-C | Substituted N- (indole-2-carbonyl) -beta-alaninamides and derivatives as antidiabetics | PFIZER (US) | 2003-01-15 | — | — | CN | claimed |
| CN-1140709-A | Substituted N- (indole-2-carbonyl) -beta-alaninamides and derivatives as antidiabetics | PFIZER (US) | 1997-01-22 | — | — | CN | claimed |
| CN-111349039-A | Preparation method of indole-2-formic acid derivative | 浙江工业大学 | 2020-06-30 | — | — | CN | disclosed |
| CN-110506043-A | COMPOUNDS USEFUL AS RET INHIBITORS | CANCER RES TECH LIMITED | 2019-11-26 | — | — | CN | disclosed |
| CN-110483366-A | Benzazole compounds and preparation method thereof, pharmaceutical composition and purposes | INST MATERIA MEDICA CAMS | 2019-11-22 | — | — | CN | disclosed |
| CN-106715422-B | Indene derivative, preparation method and the pharmaceutical composition for being used to prevent or treat retinal disease comprising it as active constituent | 忠南大学校产学协力团 | 2019-11-19 | — | — | CN | disclosed |
| CN-105658625-B | Indole amide compounds as inhibitors of cellular necrosis | 株式会社LG化学 | 2019-05-03 | — | — | CN | disclosed |
| CN-108349949-A | N- substituted indole derivatives as PGE2 receptor modulators | 爱杜西亚药品有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-105593232-B | Benzoxazoloxazinone compounds as coagulation factor Xa inhibitors | 华北制药集团新药研究开发有限责任公司 | 2018-06-26 | — | — | CN | disclosed |
| WO-2001096303-A1 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| CN-1289326-A | N-[(substituted five-membered di-or thiaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia | PFIZER PROD INC (US) | 2001-03-28 | — | — | CN | disclosed |
| CN-1279617-A | Combination of an aldose reductase inhibitor and a glycogen phosphorglase inhibitor | PFIZER PROD INC (US) | 2001-01-10 | — | — | CN | disclosed |
| CN-1058969-C | Novel substd. guanidine derivs., process for prodn. thereof, and pharmaceutical uses thereof | SUMITOMO PHARMA (JP) | 2000-11-29 | — | — | CN | disclosed |
| CN-1140709-A | Substituted N- (indole-2-carbonyl) -beta-alaninamides and derivatives as antidiabetics | PFIZER (US) | 1997-01-22 | — | — | CN | disclosed |
| EP-0249885-A2 | Heat-sensitive recording material | KANZAKI PAPER MANUFACTURING COMPANY LIMITED (JP) | 1987-12-23 | — | — | EP | disclosed |