Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 9/20 | 0.44 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 4/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19332922 | 0.89 | CDK8 (0.43) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL29398024 | 0.87 | BCL2 (0.49) | CDK8BCL2BCL2L1TNIKKDR | |
| SCHEMBL19341716 | 0.87 | BCL2 (0.49) | CDK8BCL2BCL2L1TNIKKDR | |
| SCHEMBL25586384 | 0.87 | RIPK1 (0.46) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL1701635 | 0.84 | CTNNB1 (0.51) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL16030568 | 0.84 | BCL2 (0.57) | CDK8CDK7BCL2BCL2L1TNIK | |
| SCHEMBL24165693 | 0.80 | BCL2 (0.48) | CDK8BCL2BCL2L1TNIKKDR | |
| SCHEMBL19708396 | 0.79 | BCL2 (0.45) | RIPK1BCL2BCL2L1SYKMAPK8 | |
| SCHEMBL22562914 | 0.79 | CDK8 (0.41) | RIPK1CDK8KDR | |
| SCHEMBL26938764 | 0.79 | CDK8 (0.40) | RIPK1CDK8CDK7CCNT1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114073707-A | Compositions and methods for treating systemic lupus erythematosus | 苏州亚盛药业有限公司 | 2022-02-22 | — | — | CN | disclosed |