Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.83 |
| ▸ | INSR | P06213 | 8/20 | 0.83 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886364 | 1.00 | MET (0.83) | METINSRALKEGFR | |
| SCHEMBL885893 | 0.96 | MET (0.81) | METINSRALKEGFR | |
| SCHEMBL886137 | 0.95 | MET (0.86) | METINSRALKEGFR | |
| SCHEMBL886299 | 0.94 | MET (0.83) | METINSRALKEGFR | |
| SCHEMBL886031 | 0.94 | MET (0.78) | METINSRALKEGFR | |
| SCHEMBL886347 | 0.93 | MET (0.82) | METINSRALKEGFR | |
| SCHEMBL886196 | 0.93 | MET (0.82) | METINSRALKEGFR | |
| SCHEMBL886613 | 0.93 | MET (0.77) | METINSRALKEGFR | |
| SCHEMBL2945452 | 0.93 | MET (0.77) | METINSRALKEGFR | |
| SCHEMBL886168 | 0.93 | MET (0.86) | METINSRALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |