Sugi Predict

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SCHEMBL2940490

SCHEMBL2940490

CC1C(=O)N(c2ccc(S(=O)(=O)C(F)(F)F)cc2)C(=O)N1Cc1ccncc1NC(=O)Cc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 2/20 0.61
▸ SMO Q99835 3/20 0.41
▸ KDM6B O15054 1/20 0.40
▸ KDM4D Q6B0I6 1/20 0.40
▸ KDM4C Q9H3R0 1/20 0.40
▸ TP53 P04637 1/20 0.38
▸ NAMPT P43490 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.35
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ CA5A P35218 1/20 0.34
▸ CA7 P43166 1/20 0.34
▸ CA5B Q9Y2D0 1/20 0.34
▸ CRACR2A Q9BSW2 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ TAS2R8 Q9NYW2 3/20 0.34
▸ RXFP1 Q9HBX9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2939601 0.89 IGF1R (0.59) IGF1RSMONAMPT
SCHEMBL2941779 0.89 IGF1R (0.61) IGF1RSMOKDM4DKDM4CTP53
SCHEMBL2937893 0.89 IGF1R (0.62) IGF1RSMOTP53NAMPTRXFP1
SCHEMBL2941577 0.88 IGF1R (0.60) IGF1RSMOTP53NAMPTALDH1A1
SCHEMBL2939954 0.88 IGF1R (0.60) IGF1RSMOTP53NAMPTALDH1A1
SCHEMBL2941137 0.87 IGF1R (0.58) IGF1RSMOTP53NAMPTLMNA
SCHEMBL2938743 0.87 IGF1R (0.44) IGF1RSMOKDM6BKDM4DKDM4C
SCHEMBL2939425 0.87 IGF1R (0.44) IGF1RSMOKDM6BKDM4DKDM4C
SCHEMBL2984358 0.86 IGF1R (0.61) IGF1RSMOTP53NAMPTTAS2R8
SCHEMBL2939631 0.86 IGF1R (0.57) IGF1RSMONAMPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7825115-B2 Cyclic urea compounds, preparation thereof and pharmaceutical use thereof as kinase inhibitors AVENTIS PHARMA S.A. (FR) 2010-11-02 — — US disclosed
EP-1599464-B1 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA SA (FR) 2010-09-22 — — EP disclosed
US-20080108654-A1 Cyclic Urea Compounds, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors AVENTIS PHARMA S.A. (FR) 2008-05-08 — — US disclosed
US-7354933-B2 Protein kinase inhibitors; antitumor agents; such as 5-methyl-1-quinol-4-ylmethyl-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate AVENTIS PHARMA SA (FR) 2008-04-08 — — US disclosed
US-20040248884-A1 Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors AVENTIS PHARMA S.A. (FR) 2004-12-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080108654-A1 Cyclic Urea Compounds, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors PRKG1, PRKACA, CMPK1 IGF1R 1595/4885SMO 2187/4885KDM6B 2263/4885
US-20040248884-A1 Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors PRKG1, PRKACA, PRKCA IGF1R 962/4885SMO 2697/4885KDM6B 2381/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.