Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24571213 | 1.00 | NTRK1 (0.47) | NTRK1MAPK14GRM5STIM1ORAI1 | |
| SCHEMBL22659317 | 0.91 | KCNT1 (0.47) | NTRK1MAPK14GRM5STIM1ORAI1 | |
| SCHEMBL22659083 | 0.91 | HTR2C (0.44) | NTRK1GRM5STIM1ORAI1BRAF | |
| SCHEMBL22659115 | 0.91 | ESR2 (0.45) | NTRK1MAPK14STIM1ORAI1BRAF | |
| SCHEMBL22659336 | 0.91 | HTR2C (0.44) | NTRK1STIM1ORAI1BRAFHTR2C | |
| SCHEMBL24571216 | 0.91 | KCNT1 (0.46) | NTRK1MAPK14STIM1ORAI1BRAF | |
| SCHEMBL22659082 | 0.91 | MAPK14 (0.53) | NTRK1MAPK14BRAFHTR2CMCHR1 | |
| SCHEMBL22659822 | 0.91 | LCK (0.45) | BRAFLMNA | |
| SCHEMBL22659076 | 0.91 | WDR5 (0.45) | NTRK1MAPK14GRM5STIM1ORAI1 | |
| SCHEMBL22659854 | 0.91 | KCNT1 (0.48) | NTRK1MAPK14BRAFLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966208-A2 | COMPOUNDS AND METHODS FOR TREATING CANCER | Antidote IP Holdings, LLC (US) | 2022-03-16 | — | — | EP | disclosed |