Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 2/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2941133 | 0.87 | IGF1R (0.40) | IGF1RSMO | |
| SCHEMBL2934730 | 0.86 | IGF1R (0.65) | IGF1RLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2940648 | 0.84 | IGF1R (0.57) | IGF1RLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2939817 | 0.84 | IGF1R (0.36) | IGF1RLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2939171 | 0.83 | IGF1R (0.65) | IGF1RTEAD1SMOCETPCTSS | |
| SCHEMBL2933710 | 0.82 | IGF1R (0.55) | IGF1RLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2937125 | 0.82 | IGF1R (0.60) | IGF1RLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2937942 | 0.81 | IGF1R (0.64) | IGF1RLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2938121 | 0.81 | IGF1R (0.64) | IGF1RSMO | |
| SCHEMBL2936770 | 0.81 | IGF1R (0.61) | IGF1RLMNAMAPK1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2010-09-22 | — | — | EP | disclosed |