Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22626131 | 1.00 | ATF4 (0.41) | ATF4CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22614169 | 1.00 | ATF4 (0.41) | ATF4CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22614168 | 0.85 | ATF4 (0.44) | ATF4CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29408938 | 0.85 | ATF4 (0.44) | ATF4CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22614170 | 0.85 | ATF4 (0.44) | ATF4CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22614121 | 0.85 | ATF4 (0.39) | ATF4CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29408876 | 0.85 | ATF4 (0.39) | ATF4CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22614695 | 0.85 | ATF4 (0.39) | ATF4CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22614506 | 0.82 | ATF4 (0.42) | ATF4CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22614505 | 0.82 | ATF4 (0.42) | ATF4CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237413-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094244-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-05-05 | — | — | WO | disclosed |
| CN-114206848-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-03-18 | — | — | CN | disclosed |
| EP-3962906-A1 | SUBSTITUTED CYCLOALKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2022-03-09 | — | — | EP | disclosed |