Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 6/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22613809 | 1.00 | ATF4 (0.39) | ATF4TRPA1TRPV3NR1H4KDM4E | |
| SCHEMBL22614615 | 1.00 | ATF4 (0.39) | ATF4TRPA1TRPV3NR1H4KDM4E | |
| SCHEMBL29408944 | 1.00 | ATF4 (0.39) | ATF4TRPA1TRPV3NR1H4KDM4E | |
| SCHEMBL29408880 | 0.89 | ATF4 (0.38) | ATF4LMNAMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL29408957 | 0.89 | ATF4 (0.38) | ATF4LMNAMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL22613871 | 0.89 | ATF4 (0.38) | ATF4LMNAMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL22613989 | 0.89 | ATF4 (0.38) | ATF4LMNAMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL22614502 | 0.87 | ATF4 (0.38) | ATF4TRPA1NR1H4 | |
| SCHEMBL22614219 | 0.87 | ATF4 (0.38) | ATF4TRPA1NR1H4 | |
| SCHEMBL29409041 | 0.87 | ATF4 (0.38) | ATF4TRPA1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237413-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094244-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-05-05 | — | — | WO | disclosed |
| CN-114206848-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-03-18 | — | — | CN | disclosed |
| EP-3962906-A1 | SUBSTITUTED CYCLOALKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2022-03-09 | — | — | EP | disclosed |