Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.61 |
| ▸ | HTR3B | O95264 | 1/20 | 0.61 |
| ▸ | HTR3A | P46098 | 1/20 | 0.61 |
| ▸ | BACE1 | P56817 | 1/20 | 0.61 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.61 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.61 |
| ▸ | F10 | P00742 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | KLK1 | P06870 | 1/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.51 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354084 | 1.00 | TDP1 (0.70) | TDP1HTR3EHTR3BHTR3ABACE1 | |
| Hydrochloric Acid SCHEMBL5204720 | 0.98 | TDP1 (0.68) | TDP1HTR3EHTR3BHTR3ABACE1 | |
| Hydrochloric Acid SCHEMBL31164757 | 0.98 | TDP1 (0.68) | TDP1HTR3EHTR3BHTR3ABACE1 | |
| SCHEMBL1974375 | 0.86 | RAD52 (0.67) | TDP1HTR3EHTR3BHTR3ABACE1 | |
| SCHEMBL4151145 | 0.86 | TDP1 (0.51) | TDP1HTR3EHTR3BHTR3ABACE1 | |
| Hydrochloric Acid SCHEMBL4148629 | 0.84 | TDP1 (0.50) | TDP1HTR3EHTR3BHTR3ABACE1 | |
| Hydrochloric Acid SCHEMBL5204712 | 0.84 | TDP1 (0.50) | TDP1HTR3EHTR3BHTR3ABACE1 | |
| Hydrochloric Acid SCHEMBL30012925 | 0.84 | TDP1 (0.50) | TDP1HTR3EHTR3BHTR3ABACE1 | |
| SCHEMBL656416 | 0.84 | TDP1 (0.72) | TDP1HTR3EHTR3BHTR3ABACE1 | |
| SCHEMBL30040705 | 0.84 | TDP1 (0.72) | TDP1HTR3EHTR3BHTR3ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237413-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094244-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-05-05 | — | — | WO | disclosed |
| EP-3962906-A1 | SUBSTITUTED CYCLOALKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2022-03-09 | — | — | EP | disclosed |