Human Neutrophil Defensin 1

Human Neutrophil Defensin 1

SCHEMBL29412280

CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H](NC(=O)[C@H](C)N)CSSC[C@@H](C(=O)O)NC3=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](C)NC1=O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 4/20 0.67
EPHA2 P29317 4/20 0.66
ELANE P08246 4/20 0.60
KCNA3 P22001 1/20 0.59
KCNA1 Q09470 1/20 0.59
MC4R P32245 1/20 0.58
MC1R Q01726 1/20 0.58
CHRNA7 P36544 1/20 0.57
CTSG P08311 1/20 0.57
ACE P12821 1/20 0.57
ACE2 Q9BYF1 1/20 0.57
TSLP Q969D9 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29412265 0.97 KLKB1 (0.63) KLKB1EPHA2ELANEKCNA3KCNA1
SCHEMBL29412281 0.94 ELANE (0.62) KLKB1EPHA2ELANEKCNA3KCNA1
Circulin A SCHEMBL29508768 0.85 ELANE (0.73) KLKB1EPHA2ELANECHRNA7
Vitri A SCHEMBL30132415 0.84 KCNMA1 (0.64) KLKB1EPHA2ELANEKCNA3KCNA1
SCHEMBL29362264 0.83 PCSK9 (0.58) KLKB1EPHA2ELANECHRNA7
Cycloviolacin O13 SCHEMBL30831409 0.83 ELANE (0.71) KLKB1EPHA2ELANECHRNA7
Cycloviolacin O2 SCHEMBL30497729 0.83 KCNMA1 (0.62) KLKB1EPHA2ELANEKCNA3KCNA1
SCHEMBL18375845 0.82 EPHA2 (0.58) KLKB1EPHA2ACEACE2TSLP
SCHEMBL18375815 0.82 EPHA2 (0.58) KLKB1EPHA2ACEACE2TSLP
Circulin F SCHEMBL29508763 0.82 ELANE (0.69) KLKB1EPHA2ELANECHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 229 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026101236-A1 PEPTIDES SPECIFICALLY BINDING TO CCR8, AND USE THEREOF 경희대학교 산학협력단 2026-05-15 WO claimed
US-20260000782-A1 ITGB2-MEDIATED DRUG DELIVERY SYSTEM TWINPIG BIOLAB INC. (KR) 2026-01-01 US claimed
US-20250228951-A1 NOVEL-PEPTIDE-BASED ANTICANCER IMMUNOTHERAPEUTIC AGENT TWINPIG BIOLAB INC. (KR) 2025-07-17 US claimed
CN-112689758-B Device and method for checking the effect of a drug on microorganisms 上海宜晟生物科技有限公司 2025-03-28 CN claimed
EP-4512410-A1 NOVEL-PEPTIDE-BASED ANTICANCER IMMUNOTHERAPEUTIC AGENT Twinpig Biolab, Inc. (KR) 2025-02-26 EP claimed
EP-4512411-A2 ITGB2-MEDIATED DRUG DELIVERY SYSTEM Twinpig Biolab, Inc. (KR) 2025-02-26 EP claimed
CN-118453517-B Composition for targeted binding of LDLR and application thereof 杭州珞米医疗科技有限公司 2024-10-08 CN claimed
EP-3554532-B1 HBD2 FOR USE IN THE TREATMENT OF INFLAMMATORY CONDITIONS OF THE LUNGS DEFENSIN THERAPEUTICS APS (DK) 2024-09-25 EP claimed
CN-118453517-A Composition for targeted binding of LDLR and application thereof 杭州珞米医疗科技有限公司 2024-08-09 CN claimed
WO-2023195805-A9 ITGB2-MEDIATED DRUG DELIVERY SYSTEM 트윈피그바이오랩(주) 2024-07-11 WO claimed
WO-2023195805-A2 ITGB2-MEDIATED DRUG DELIVERY SYSTEM 트윈피그바이오랩(주) 2023-10-12 WO claimed
US-11725227-B2 Devices and methods for examining drug effects on microorganisms ESSENLIX CORPORATION (US) 2023-08-15 US claimed
CN-116087515-A Biomarker combinations for gastric cancer diagnosis 复旦大学附属中山医院 2023-05-09 CN claimed
US-20230067261-A1 METHODS FOR TREATING INFLAMMATORY CONDITIONS OF THE LUNGS DEFENSIN THERAPEUTICS APS (DK) 2023-03-02 US claimed
EP-4103585-A1 PEPTIDES TARGETING MACROPHAGES, AND CONJUGATES, COMPOSITIONS, AND USES THEREOF Twinpig Biolab, Inc. (KR) 2022-12-21 EP claimed
US-20220354957-A1 PEPTIDES TARGETING MACROPHAGES, AND CONJUGATES, COMPOSITIONS, AND USES THEREOF TWINPIG BIOLAB, INC. (KR) 2022-11-10 US claimed
WO-2022234346-A1 PEPTIDES TARGETING MACROPHAGES, AND CONJUGATES, COMPOSITIONS, AND USES THEREOF TWINPIG BIOLAB, INC. (KR) 2022-11-10 WO claimed
US-11484601-B2 Targeting M2-like tumor-associated macrophages by using melittin-based proapoptotic peptide TWINPIGBIOLAB INC. (KR) 2022-11-01 US claimed
US-11413328-B2 Methods for treating inflammatory conditions of the lungs NOVOZYMES A/S (DK) 2022-08-16 US claimed
US-20220175848-A1 METHODS AND COMPOSITIONS FOR CELL THERAPY THE BRIGHAM AND WOMEN'S HOSPITAL, INC. 2022-06-09 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260000782-A1 ITGB2-MEDIATED DRUG DELIVERY SYSTEM ITGB8, ITGB2, ITGA8 KLKB1 229/4885EPHA2 128/4885ELANE 1360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.