Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.61 |
| ▸ | RAB9A | P51151 | 9/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | AGTR1 | P30556 | 6/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12720839 | 0.86 | NPC1 (0.70) | NPC1RAB9AGAAKMT2AAGTR1 | |
| SCHEMBL12720817 | 0.85 | NPC1 (0.76) | NPC1RAB9AGAAKMT2AAGTR1 | |
| SCHEMBL12720926 | 0.83 | NPC1 (0.60) | NPC1RAB9AGAAKMT2AAGTR1 | |
| SCHEMBL27178051 | 0.80 | NPC1 (0.70) | NPC1RAB9AGAAKMT2AAGTR1 | |
| SCHEMBL27178164 | 0.80 | NPC1 (0.70) | NPC1RAB9AGAAKMT2AAGTR1 | |
| SCHEMBL27178057 | 0.80 | NPC1 (0.70) | NPC1RAB9AGAAKMT2AAGTR1 | |
| SCHEMBL12720841 | 0.77 | RAB9A (0.88) | NPC1RAB9AGAAKMT2AAGTR1 | |
| SCHEMBL30873792 | 0.77 | RAB9A (0.72) | NPC1RAB9AGAAKMT2AAGTR1 | |
| SCHEMBL30826075 | 0.77 | NPC1 (0.52) | NPC1RAB9AGAAKMT2AAGTR1 | |
| SCHEMBL27178185 | 0.77 | NPC1 (0.52) | NPC1RAB9AGAAKMT2AAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4204401-A1 | COMPOUNDS FOR AND METHODS OF TREATING DISEASES | Alterity Therapeutics Limited (AU) | 2023-07-05 | — | — | EP | disclosed |
| WO-2022040747-A1 | COMPOUNDS FOR AND METHODS OF TREATING DISEASES | Alterity Therapeutics Limited (AU) | 2022-03-03 | — | — | WO | disclosed |