Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CCNH | P51946 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23547410 | 0.81 | HAVCR2 (0.31) | CDK2CDK5CDK5R1CCNT1CDK7 | |
| SCHEMBL26630222 | 0.75 | PDE4A (0.32) | — | |
| SCHEMBL19748848 | 0.75 | TDP1 (0.35) | CDK2CDK5CDK5R1DYRK3CCNA2 | |
| SCHEMBL29412976 | 0.74 | MALT1 (0.37) | — | |
| SCHEMBL31201490 | 0.72 | TDP1 (0.33) | — | |
| SCHEMBL26730569 | 0.72 | LRRK2 (0.38) | CDK2CDK5CDK5R1CCNA2CCNT1 | |
| SCHEMBL26630077 | 0.70 | CCNT1 (0.49) | CDK2CDK5CDK5R1CCNT1CDK7 | |
| SCHEMBL26605792 | 0.70 | CCNT1 (0.34) | CDK2CDK5CDK5R1CCNT1CDK7 | |
| SCHEMBL26630017 | 0.69 | CDK2 (0.34) | CDK2CDK5CDK5R1CCNT1CDK7 | |
| SCHEMBL22185649 | 0.68 | TNF (0.49) | CDK2CDK5CDK5R1DYRK3CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022061155-A1 | IMIDAZOPYRIDAZINE AND IMIDAZOPYRAZINE COMPOUNDS AS INHIBITORS OF CDK7 | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2022-03-24 | — | — | WO | disclosed |