Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22468557 | 0.84 | MEN1 (0.51) | KMT2AMEN1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL15636331 | 0.84 | MEN1 (0.54) | KMT2AMEN1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL30703146 | 0.83 | SMN1; SMN2 (0.49) | KMT2AMEN1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL30703145 | 0.82 | MEN1 (0.49) | KMT2AMEN1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL20399800 | 0.82 | NPC1 (0.53) | KMT2AMEN1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL8326473 | 0.80 | MEN1 (0.57) | KMT2AMEN1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL9217126 | 0.80 | KMT2A (0.56) | KMT2AMEN1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL2673587 | 0.80 | KMT2A (0.56) | KMT2AMEN1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL10197546 | 0.80 | KMT2A (0.56) | KMT2AMEN1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL25259870 | 0.79 | MEN1 (0.55) | KMT2AMEN1NPSR1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053523-B | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2022-03-25 | — | — | CN | disclosed |