Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Loxapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 known ✓ | P21917 | 6/20 | 0.82 |
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.82 |
| ▸ | DRD3 known ✓ | P35462 | 6/20 | 0.82 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.82 |
| ▸ | HTR2C known ✓ | P28335 | 4/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.82 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.82 |
| ▸ | HRH1 | P35367 | 4/20 | 0.82 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loxapine SCHEMBL5500954 | 1.00 | LMNA (1.00) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL30201498 | 1.00 | LMNA (1.00) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL41643 | 1.00 | LMNA (1.00) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL29482385 | 0.90 | HRH4 (1.00) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL30324780 | 0.90 | HRH4 (1.00) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL29374082 | 0.90 | HRH4 (1.00) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL19386241 | 0.90 | HRH4 (1.00) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL94146 | 0.90 | HRH4 (1.00) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| Loxapine SCHEMBL41644 | 0.90 | LMNA (0.82) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5946392 | 0.90 | MEN1 (0.81) | LMNAMEN1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3962455-A1 | NEW PHARMACEUTICAL COMPOSITION FOR DRUG DELIVERY | Orexo AB (SE) | 2022-03-09 | — | — | EP | disclosed |