Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28711691 | 1.00 | SCN9A (0.44) | SCN9AGRM5SCN10A | |
| SCHEMBL14661987 | 0.89 | SCN9A (0.47) | SCN9ASCN10A | |
| SCHEMBL875745 | 0.82 | SCN9A (0.46) | SCN9AGRM5SCN10A | |
| SCHEMBL29416783 | 0.80 | FFAR4 (0.44) | GRM5 | |
| SCHEMBL28711698 | 0.80 | FFAR4 (0.44) | GRM5 | |
| SCHEMBL2026509 | 0.78 | GRM5 (0.43) | SCN9AGRM5SCN10A | |
| SCHEMBL9107191 | 0.78 | KDM4E (0.50) | SCN9AGRM5SCN10A | |
| SCHEMBL876946 | 0.78 | ALOX5AP (0.41) | SCN9AGRM5SCN10A | |
| SCHEMBL22809751 | 0.77 | SCN10A (0.51) | SCN9AGRM5SCN10A | |
| SCHEMBL28713212 | 0.77 | SCN9A (0.40) | SCN9AGRM5SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114149423-B | Tetrahydropyridopyrimidinedione derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-114149423-A | Tetrahydropyridopyrimidine diketone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-03-08 | — | — | CN | disclosed |