Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.51 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 13/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18570880 | 0.86 | SCN10A (0.50) | SCN10ASCN8ASCN9A | |
| SCHEMBL18570394 | 0.82 | SCN10A (0.52) | SCN10ASCN8ASCN9A | |
| SCHEMBL875745 | 0.82 | SCN9A (0.46) | SCN10AGRM5SCN9A | |
| SCHEMBL14661987 | 0.77 | SCN9A (0.47) | SCN10ASCN9A | |
| SCHEMBL28711691 | 0.77 | SCN9A (0.44) | SCN10AGRM5SCN9A | |
| SCHEMBL29416760 | 0.77 | SCN9A (0.44) | SCN10AGRM5SCN9A | |
| SCHEMBL5991889 | 0.75 | LMNA (0.46) | SCN10ASCN8AEPAS1TDP1 | |
| SCHEMBL20535300 | 0.74 | RHEB (0.51) | EPAS1TDP1 | |
| SCHEMBL21858465 | 0.73 | PPARG (0.52) | TDP1 | |
| SCHEMBL875647 | 0.73 | ALDH1A1 (0.39) | SCN10ASCN8ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |