Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | CDC25B | P30305 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948396 | 0.86 | TSHR (0.56) | TSHRCDC25BALDH1A1HSD17B10TDP1 | |
| SCHEMBL30385424 | 0.84 | TSHR (0.67) | TSHRCDC25BALDH1A1HSD17B10TDP1 | |
| SCHEMBL2002577 | 0.84 | TSHR (0.67) | TSHRCDC25BALDH1A1HSD17B10TDP1 | |
| SCHEMBL7467330 | 0.84 | TSHR (0.70) | TSHRCDC25BALDH1A1HSD17B10TDP1 | |
| SCHEMBL21052524 | 0.83 | TSHR (0.56) | TSHRCDC25BALDH1A1HSD17B10TDP1 | |
| SCHEMBL16957354 | 0.83 | TSHR (0.44) | TSHRALDH1A1HSD17B10LMNACA12 | |
| SCHEMBL23294946 | 0.82 | ALDH1A1 (0.55) | TSHRCDC25BALDH1A1HSD17B10LMNA | |
| SCHEMBL953393 | 0.81 | TSHR (0.53) | TSHRCDC25BALDH1A1HSD17B10LMNA | |
| SCHEMBL28351196 | 0.81 | TSHR (0.53) | TSHRCDC25BALDH1A1HSD17B10TDP1 | |
| SCHEMBL11270794 | 0.80 | TSHR (0.66) | TSHRCDC25BALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076367-B2 | Benzimidazolylidene propane-1,3-dione derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2011-12-13 | — | — | US | disclosed |
| US-20100173946-A1 | BENZIMIDAZOLYLIDENE PROPANE-1,3-DIONE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2010-07-08 | — | — | US | disclosed |
| US-7709519-B2 | Benzimidazolylidene propane-1,3 dione derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2010-05-04 | — | — | US | disclosed |
| US-20090018177-A1 | Propane-1,3-Dione Derivative or Salt Thereof | ASTELLAS PHARMA INC. (JP) | 2009-01-15 | — | — | US | disclosed |
| EP-1752452-A9 | PROPANE-1,3-DIONE DERIVATIVE OR ITS SALT | Astellas Pharma Inc. (JP) | 2007-12-12 | — | — | EP | disclosed |
| CN-1964950-A | Propane-1,3-dione derivative or its salt | ASTELLAS PHARMA INC (JP) | 2007-05-16 | — | — | CN | disclosed |
| EP-1752452-A1 | PROPANE-1,3-DIONE DERIVATIVE OR ITS SALT | Astellas Pharma Inc. (JP) | 2007-02-14 | — | — | EP | disclosed |
| CN-1070191-C | Novel quinolone-or naphthalenone-carboxylic acid derivatives or salts thereof | TOYAMA CHEMICAL CO LTD (JP) | 2001-08-29 | — | — | CN | disclosed |
| CN-1158611-A | Novel quinolone-or naphthyridonecarboxylic acid derivative or salt thereof | TOYAMA CHEMICAL CO LTD (JP) | 1997-09-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018177-A1 | Propane-1,3-Dione Derivative or Salt Thereof | GPER1, GNRHR, AR | TSHR 169/4885CDC25B 4359/4885ALDH1A1 719/4885 |
| US-20100173946-A1 | BENZIMIDAZOLYLIDENE PROPANE-1,3-DIONE DERIVATIVE OR SALT THEREOF | GPER1, GNRHR, AR | TSHR 156/4885CDC25B 3898/4885ALDH1A1 1046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.