Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30673114 | 0.89 | ALDH1A1 (0.39) | ATMHSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL15425318 | 0.86 | PDE8B (0.43) | PDE8BKDM1AATMHSD17B10ALDH1A1 | |
| SCHEMBL15425312 | 0.86 | PDE8B (0.43) | PDE8BKDM1AATMHSD17B10ALDH1A1 | |
| SCHEMBL28171957 | 0.85 | PDE8B (0.47) | PDE8BKDM1AATMHSD17B10ALDH1A1 | |
| SCHEMBL20805946 | 0.85 | PDE8B (0.47) | PDE8BKDM1AATMHSD17B10ALDH1A1 | |
| SCHEMBL20805993 | 0.85 | PDE8B (0.47) | PDE8BKDM1AATMHSD17B10ALDH1A1 | |
| SCHEMBL20805948 | 0.84 | PDE8B (0.46) | PDE8BKDM1AATMHSD17B10ALDH1A1 | |
| SCHEMBL20805953 | 0.84 | PDE8B (0.46) | PDE8BKDM1AATMHSD17B10ALDH1A1 | |
| SCHEMBL192841 | 0.83 | POLB (0.51) | PDE8BKDM1AATMHSD17B10ALDH1A1 | |
| SCHEMBL282977 | 0.83 | POLB (0.51) | PDE8BKDM1AATMHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3974413-A1 | ANTIDIABETIC SUBSTITUTED HETEROARYL COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2022-03-30 | — | — | EP | disclosed |