Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31498617 | 0.89 | MAPT (0.42) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL20819238 | 0.85 | MAPT (0.45) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL20819239 | 0.85 | MAPT (0.45) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL20466960 | 0.85 | ALDH1A1 (0.42) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL872773 | 0.85 | BRD4 (0.49) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL872772 | 0.85 | BRD4 (0.49) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL19973040 | 0.79 | MAPT (0.46) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL19973041 | 0.79 | MAPT (0.46) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL18591884 | 0.76 | ALDH1A1 (0.44) | MAPTALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL30411459 | 0.74 | ALDH1A1 (0.53) | MAPTALDH1A1HPGDHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11267822-B2 | BET bromodomain protein degraders with cleavable linkers | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11267822-B2 | BET bromodomain protein degraders with cleavable linkers | BRD4, BET1, BRWD1 | MAPT 1300/4885ALDH1A1 3470/4885HPGD 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.