Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA3 | P07451 | 1/20 | 0.47 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7747191 | 0.84 | ESR1 (0.54) | ESR1ESR2PGRHCAR2PKM | |
| SCHEMBL7747194 | 0.84 | ESR1 (0.54) | ESR1ESR2PGRHCAR2PKM | |
| SCHEMBL660161 | 0.79 | HPGD (0.60) | ESR1ESR2PGRPKMKDM4E | |
| SCHEMBL660160 | 0.79 | HPGD (0.60) | ESR1ESR2PGRPKMKDM4E | |
| SCHEMBL1237240 | 0.78 | CA1 (0.55) | ESR1ESR2PGRHCAR2PKM | |
| SCHEMBL6644791 | 0.78 | HDAC2 (0.57) | ESR1ESR2PGRHCAR2PKM | |
| SCHEMBL1237242 | 0.78 | CA1 (0.55) | ESR1ESR2PGRHCAR2PKM | |
| SCHEMBL6644786 | 0.78 | HDAC2 (0.57) | ESR1ESR2PGRHCAR2PKM | |
| SCHEMBL6538970 | 0.78 | NR1H4 (0.51) | CA12CA1CA2CA9CA14 | |
| SCHEMBL6642558 | 0.78 | ALDH1A1 (0.55) | ESR1ESR2PGRKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231147-A2 | COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER | Novartis AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009076170-A2 | COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER | NOVARTIS AG (CH) | 2009-06-18 | — | — | WO | disclosed |
| EP-2004163-A2 | COMBINATIONS COMPRISING MTOR INHIBITORS FOR TREATING CANCER | Novartis Pharma AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007124252-A2 | COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER | NOVARTIS AG (CH) | 2007-11-01 | — | — | WO | disclosed |