Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Otamixaban. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 known ✓ | P00742 | 20/20 | 1.00 |
| ▸ | PRSS1 | P07477 | 18/20 | 1.00 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 5/20 | 0.81 |
| ▸ | PLG | P00747 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Otamixaban SCHEMBL12447697 | 1.00 | F10 (1.00) | F10PRSS1TMPRSS2F2PLG | |
| Otamixaban SCHEMBL52983 | 1.00 | F10 (1.00) | F10PRSS1TMPRSS2F2PLG | |
| Otamixaban SCHEMBL12589586 | 1.00 | F10 (1.00) | F10PRSS1TMPRSS2F2PLG | |
| Otamixaban SCHEMBL16588897 | 0.99 | F10 (0.98) | F10PRSS1TMPRSS2F2PLG | |
| Otamixaban SCHEMBL7890763 | 0.99 | F10 (0.98) | F10PRSS1TMPRSS2F2PLG | |
| SCHEMBL12805269 | 0.93 | F10 (0.86) | F10PRSS1TMPRSS2F2PLG | |
| SCHEMBL15489295 | 0.92 | F10 (1.00) | F10PRSS1TMPRSS2F2PLG | |
| SCHEMBL14542917 | 0.92 | F10 (0.86) | F10PRSS1TMPRSS2F2PLG | |
| SCHEMBL13160832 | 0.92 | F10 (1.00) | F10PRSS1TMPRSS2F2PLG | |
| SCHEMBL19222680 | 0.92 | F10 (0.86) | F10PRSS1TMPRSS2F2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4714407-A2 | DEVICES TO PROVIDE HANDS FREE SCLERAL DEPRESSION DURING OPHTHALMIC PROCEDURES | Alcon Inc. (CH) | 2026-03-25 | — | — | EP | disclosed |
| EP-3157408-B1 | DEVICES TO PROVIDE HANDS FREE SCLERAL DEPRESSION DURING OPHTHALMIC PROCEDURES | ALCON INC (CH) | 2026-03-25 | — | — | EP | disclosed |
| US-20250057694-A1 | DEVICES AND METHODS TO PROVIDE HANDS FREE SCLERAL DEPRESSION AND ILLUMINATION DURING OPHTHALMIC PROCEDURES | Ganihand, LLC (US) | 2025-02-20 | — | — | US | disclosed |
| US-11266395-B2 | Devices and methods to provide hands free scleral depression during ophthalmic procedures | Ganihand, LLC (US) | 2022-03-08 | — | — | US | disclosed |