Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Otamixaban. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 known ✓ | P00742 | 20/20 | 1.00 |
| ▸ | PRSS1 | P07477 | 18/20 | 1.00 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 5/20 | 0.81 |
| ▸ | PLG | P00747 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Otamixaban SCHEMBL12447697 | 1.00 | F10 (1.00) | F10PRSS1TMPRSS2F2PLG | |
| Otamixaban SCHEMBL29426323 | 1.00 | F10 (1.00) | F10PRSS1TMPRSS2F2PLG | |
| Otamixaban SCHEMBL52983 | 1.00 | F10 (1.00) | F10PRSS1TMPRSS2F2PLG | |
| Otamixaban SCHEMBL16588897 | 0.99 | F10 (0.98) | F10PRSS1TMPRSS2F2PLG | |
| Otamixaban SCHEMBL7890763 | 0.99 | F10 (0.98) | F10PRSS1TMPRSS2F2PLG | |
| SCHEMBL12805269 | 0.93 | F10 (0.86) | F10PRSS1TMPRSS2F2PLG | |
| SCHEMBL15489295 | 0.92 | F10 (1.00) | F10PRSS1TMPRSS2F2PLG | |
| SCHEMBL14542917 | 0.92 | F10 (0.86) | F10PRSS1TMPRSS2F2PLG | |
| SCHEMBL13160832 | 0.92 | F10 (1.00) | F10PRSS1TMPRSS2F2PLG | |
| SCHEMBL19222680 | 0.92 | F10 (0.86) | F10PRSS1TMPRSS2F2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7970581-B2 | Methods of calculating differences of binding affinities between congeneric pairs of ligands by way of a displaced solvent functional | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-06-28 | — | — | US | disclosed |
| US-7970580-B2 | Methods of calculating differences of binding affinities between congeneric pairs of ligands by way of a displaced solvent functional | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-06-28 | — | — | US | disclosed |
| US-20100241411-A1 | Methods of Calculating Differences of Binding Affinities Between Congeneric Pairs of Ligands by Way of a Displaced Solvent Functional | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-09-23 | — | — | US | disclosed |
| US-7756674-B2 | Methods of calculating differences of binding affinities between congeneric pairs of ligands by way of a displaced solvent functional | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2010-07-13 | — | — | US | disclosed |
| US-20090037136-A1 | Methods of calculating differences of binding affinities between congeneric pairs of ligands by way of a displaced solvent functional | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-02-05 | — | — | US | disclosed |
| US-20070111947-A1 | Fibrin targeted therapeutics | MCMURRY THOMAS J | 2007-05-17 | — | — | US | disclosed |
| WO-2007047608-A2 | FIBRIN TARGETED THERAPEUTICS | EPIX PHARMACEUTICALS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070111947-A1 | Fibrin targeted therapeutics | FGB, F13B, F2 | F10 15/4885PRSS1 170/4885TMPRSS2 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.