Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 2/20 | 0.39 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26732573 | 1.00 | TSHR (0.49) | TSHRCASP3NLRP3CDK1MCL1 | |
| SCHEMBL26732572 | 0.95 | TSHR (0.52) | TSHRCASP3NLRP3CDK1MCL1 | |
| SCHEMBL29426511 | 0.86 | TSHR (0.48) | TSHRCASP3NLRP3MCL1KDM4E | |
| SCHEMBL26733144 | 0.86 | TSHR (0.48) | TSHRCASP3NLRP3MCL1KDM4E | |
| SCHEMBL24257391 | 0.86 | TSHR (0.53) | TSHRCASP3NLRP3MCL1KDM4E | |
| SCHEMBL29426475 | 0.86 | TSHR (0.53) | TSHRCASP3NLRP3MCL1KDM4E | |
| SCHEMBL29426501 | 0.85 | TSHR (0.47) | TSHRCASP3NLRP3CDK1MCL1 | |
| SCHEMBL29426497 | 0.85 | TSHR (0.47) | TSHRCASP3NLRP3CDK1MCL1 | |
| SCHEMBL29426519 | 0.85 | TSHR (0.47) | TSHRCASP3NLRP3CDK1MCL1 | |
| SCHEMBL26732856 | 0.85 | TSHR (0.47) | TSHRCASP3NLRP3CDK1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196125-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | Denali Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022036204-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-02-17 | — | — | WO | disclosed |