Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 9/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26733172 | 1.00 | TSHR (0.48) | TSHRAKR1B1NLRP3SMN1; SMN2MAPT | |
| SCHEMBL26733171 | 0.93 | TSHR (0.48) | TSHRAKR1B1NLRP3SMN1; SMN2MAPT | |
| SCHEMBL26732653 | 0.86 | TSHR (0.48) | TSHRAKR1B1NLRP3MAPTGPR139 | |
| SCHEMBL29426503 | 0.86 | TSHR (0.48) | TSHRAKR1B1NLRP3MAPTGPR139 | |
| SCHEMBL26733170 | 0.86 | TSHR (0.48) | TSHRAKR1B1NLRP3MAPTGPR139 | |
| SCHEMBL29426566 | 0.84 | NLRP3 (0.63) | TSHRAKR1B1NLRP3MAPTGPR139 | |
| SCHEMBL26630481 | 0.84 | NLRP3 (0.53) | TSHRAKR1B1NLRP3MAPTGPR139 | |
| SCHEMBL26732911 | 0.84 | NLRP3 (0.63) | TSHRAKR1B1NLRP3MAPTGPR139 | |
| SCHEMBL26733141 | 0.83 | TSHR (0.50) | TSHRAKR1B1NLRP3CYP1A2CYP3A4 | |
| SCHEMBL24077078 | 0.83 | CYP2C9 (0.55) | AKR1B1NLRP3SMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196125-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | Denali Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022036204-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-02-17 | — | — | WO | disclosed |