Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.47 |
| ▸ | GPR139 | Q6DWJ6 | 14/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26732715 | 1.00 | NLRP3 (0.47) | NLRP3GPR139TSHR | |
| SCHEMBL24077038 | 0.90 | NLRP3 (0.47) | NLRP3GPR139 | |
| SCHEMBL24077012 | 0.90 | GAA (0.47) | NLRP3GPR139 | |
| SCHEMBL29426561 | 0.89 | NLRP3 (0.48) | NLRP3GPR139TSHR | |
| SCHEMBL26630479 | 0.89 | NLRP3 (0.48) | NLRP3GPR139TSHR | |
| SCHEMBL30636643 | 0.88 | NLRP3 (0.46) | NLRP3GPR139 | |
| SCHEMBL29426566 | 0.85 | NLRP3 (0.63) | NLRP3GPR139TSHR | |
| SCHEMBL26732911 | 0.85 | NLRP3 (0.63) | NLRP3GPR139TSHR | |
| SCHEMBL26738768 | 0.85 | TSHR (0.46) | NLRP3GPR139TSHR | |
| SCHEMBL26732740 | 0.82 | NLRP3 (0.49) | NLRP3GPR139TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196125-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | Denali Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022036204-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-02-17 | — | — | WO | disclosed |