SCHEMBL29430118

SCHEMBL29430118

COc1ccccc1NC(=O)c1c(N)cccc1Sc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.73

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.53
▸ KMT2A Q03164 4/20 0.53
▸ RORC P51449 1/20 0.51
▸ ALDH1A1 P00352 4/20 0.49
▸ PKM P14618 2/20 0.49
▸ CRHBP P24387 1/20 0.49
▸ CRHR2 Q13324 1/20 0.49
▸ MAPT P10636 3/20 0.47
▸ RECQL P46063 1/20 0.47
▸ DUSP3 P51452 1/20 0.47
▸ PTPN5 P54829 1/20 0.47
▸ PTPN11 Q06124 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ MAOB P27338 1/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.45
▸ TSHR P16473 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.45
▸ TRPV1 Q8NER1 1/20 0.45
▸ KCNMA1 Q12791 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17103173 1.00 MEN1 (0.53) MEN1KMT2ARORCALDH1A1PKM
Hydrochloric Acid SCHEMBL17103200 0.99 MEN1 (0.52) MEN1KMT2ARORCALDH1A1PKM
Sulfuric Acid SCHEMBL17103345 0.96 KMT2A (0.52) MEN1KMT2ARORCALDH1A1PKM
Sulfuric Acid SCHEMBL17103341 0.96 KMT2A (0.52) MEN1KMT2ARORCALDH1A1PKM
SCHEMBL17103196 0.89 ALDH1A1 (0.49) MEN1KMT2AALDH1A1PKMCRHBP
SCHEMBL17103220 0.89 KMT2A (0.54) MEN1KMT2ARORCALDH1A1PKM
SCHEMBL17122765 0.89 MEN1 (0.54) MEN1KMT2ARORCALDH1A1PKM
SCHEMBL17103449 0.89 ALDH1A1 (0.43) MEN1KMT2ARORCALDH1A1PKM
SCHEMBL17122561 0.89 KMT2A (0.55) MEN1KMT2AALDH1A1PKMCRHBP
SCHEMBL17228270 0.89 ALDH1A1 (0.48) MEN1KMT2AALDH1A1PKMCRHBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122055369-A Bridged tricyclic carbamoyl pyridone compounds and uses thereof 吉利德科学公司 2026-05-15 — — CN disclosed
CN-122055373-A Bridged tricyclic carbamoyl pyridone compounds and uses thereof 吉利德科学公司 2026-05-15 — — CN disclosed
EP-4598934-A1 4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE GILEAD SCIENCES, INC. (US) 2025-08-13 — — EP disclosed
EP-4577242-A1 DOSING AND SCHEDULING REGIMEN FOR BROADLY NEUTRALIZING ANTIBODIES GILEAD SCIENCES, INC. (US) 2025-07-02 — — EP disclosed
WO-2025137245-A1 SOLID FORMS OF HIV INTEGRASE INHIBITORS GILEAD SCIENCES, INC. (US) 2025-06-26 — — WO disclosed
WO-2025080850-A1 BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. (US) 2025-04-17 — — WO disclosed
WO-2025080863-A1 BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. (US) 2025-04-17 — — WO disclosed
WO-2025080879-A1 BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. (US) 2025-04-17 — — WO disclosed
CN-118369325-A Therapeutic compounds for HIV virus infection 吉利德科学公司 2024-07-19 — — CN disclosed
CN-118355020-A Therapeutic compounds for HIV virus infection 吉利德科学公司 2024-07-16 — — CN disclosed
CN-116529258-A Interleukin-2-Fc fusion proteins and methods of use 吉利德科学公司 2023-08-01 — — CN disclosed
CN-116437958-A Method for identifying HIV patients susceptible to therapy with gp120 CD4 binding site directed antibodies 吉利德科学公司 2023-07-14 — — CN disclosed
EP-4204092-A1 MULTI-SPECIFIC ANTIGEN BINDING MOLECULES TARGETING HIV AND METHODS OF USE GILEAD SCIENCES, INC. (US) 2023-07-05 — — EP disclosed
EP-4192474-A1 PRODRUGS OF PHOSPHONAMIDE NUCLEOTIDE ANALOGUES AND THEIR PHARMACEUTICAL USE GILEAD SCIENCES, INC. (US) 2023-06-14 — — EP disclosed
CN-116194144-A Prodrugs of phosphoramide nucleotide analogs and pharmaceutical uses thereof 吉利德科学公司 2023-05-30 — — CN disclosed
CN-116157416-A HIV-targeting multispecific antigen-binding molecules and methods of use thereof 吉利德科学公司 2023-05-23 — — CN disclosed
EP-4121437-A1 PRODRUGS OF 4'-C-SUBSTITUTED-2-HALO-2'-DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME GILEAD SCIENCES, INC. (US) 2023-01-25 — — EP disclosed
WO-2022103758-A1 METHODS OF IDENTIFYING HIV PATIENTS SENSITIVE TO THERAPY WITH gp120 CD4 BINDING SITE-DIRECTED ANTIBODIES GILEAD SCIENCES, INC. (US) 2022-05-19 — — WO disclosed
WO-2022087149-A2 INTERLEUKIN-2-FC FUSION PROTEINS AND METHODS OF USE GILEAD SCIENCES, INC. (US) 2022-04-28 — — WO disclosed
WO-2022046644-A1 MULTI-SPECIFIC ANTIGEN BINDING MOLECULES TARGETING HIV AND METHODS OF USE GILEAD SCIENCES, INC. (US) 2022-03-03 — — WO disclosed
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