Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Elcubragistat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL known ✓ | Q99685 | 19/20 | 0.89 |
| ▸ | ABHD6 | Q9BV23 | 16/20 | 0.89 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.89 |
| ▸ | PLA2G7 | Q13093 | 10/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Elcubragistat SCHEMBL20168245 | 1.00 | MGLL (0.89) | MGLLABHD6CYP2D6PLA2G7 | |
| Elcubragistat SCHEMBL15100632 | 0.94 | MGLL (1.00) | MGLLABHD6CYP2D6PLA2G7 | |
| SCHEMBL23349060 | 0.93 | MGLL (1.00) | MGLLABHD6CYP2D6PLA2G7 | |
| Elcubragistat SCHEMBL29430972 | 0.93 | MGLL (0.98) | MGLLABHD6CYP2D6PLA2G7 | |
| Elcubragistat SCHEMBL20168257 | 0.93 | MGLL (0.98) | MGLLABHD6CYP2D6PLA2G7 | |
| Elcubragistat SCHEMBL20166890 | 0.93 | MGLL (0.98) | MGLLABHD6CYP2D6PLA2G7 | |
| Elcubragistat SCHEMBL29430943 | 0.93 | MGLL (0.98) | MGLLABHD6CYP2D6PLA2G7 | |
| Elcubragistat SCHEMBL29431066 | 0.91 | MGLL (0.83) | MGLLABHD6CYP2D6PLA2G7 | |
| Elcubragistat SCHEMBL20168658 | 0.91 | MGLL (0.83) | MGLLABHD6CYP2D6PLA2G7 | |
| Elcubragistat SCHEMBL20167123 | 0.89 | MGLL (0.89) | MGLLABHD6CYP2D6PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11993588-B2 | Crystalline forms of a MAGL inhibitor | H. LUNDBECK A/S (DK) | 2024-05-28 | — | — | US | claimed |
| US-20220235037-A1 | CRYSTALLINE FORMS OF A MAGL INHIBITOR | H. LUNDBECK A/S (DK) | 2022-07-28 | — | — | US | claimed |
| US-11993588-B2 | Crystalline forms of a MAGL inhibitor | H. LUNDBECK A/S (DK) | 2024-05-28 | — | — | US | disclosed |
| EP-3964503-B1 | A CRYSTALLINE FORM OF A MAGL INHIBITOR | H LUNDBECK AS (DK) | 2023-11-08 | — | — | EP | disclosed |
| CN-115093382-A | Crystalline forms of a MAGL inhibitor | H.隆德贝克有限公司 | 2022-09-23 | — | — | CN | disclosed |
| US-20220235037-A1 | CRYSTALLINE FORMS OF A MAGL INHIBITOR | H. LUNDBECK A/S (DK) | 2022-07-28 | — | — | US | disclosed |
| CN-110291083-B | Crystalline forms of a MAGL inhibitor | H.隆德贝克有限公司 | 2022-06-17 | — | — | CN | disclosed |
| EP-3964503-A1 | A CRYSTALLINE FORM OF A MAGL INHIBITOR | H. Lundbeck A/S (DK) | 2022-03-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220235037-A1 | CRYSTALLINE FORMS OF A MAGL INHIBITOR | MAG, MAGI3, PYM1 | MGLL 5/4885ABHD6 462/4885CYP2D6 4164/4885 |
| US-11993588-B2 | Crystalline forms of a MAGL inhibitor | MAG, MAGI3, PYM1 | MGLL 5/4885ABHD6 462/4885CYP2D6 4164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.