Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAA50 | Q9GZZ1 | 1/20 | 0.56 |
| ▸ | APLNR | P35414 | 4/20 | 0.48 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.46 |
| ▸ | NMUR2 | Q9GZQ4 | 4/20 | 0.45 |
| ▸ | NMUR1 | Q9HB89 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | RAMP3 | O60896 | 4/20 | 0.42 |
| ▸ | CALCR | P30988 | 4/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495351 | 0.94 | NAA50 (0.54) | NAA50APLNRNTSR1NMUR2NMUR1 | |
| SCHEMBL30608626 | 0.91 | NAA50 (0.53) | NAA50APLNRNTSR1NMUR2NMUR1 | |
| SCHEMBL30608607 | 0.90 | NAA50 (0.53) | NAA50APLNRNTSR1NMUR2NMUR1 | |
| SCHEMBL30608624 | 0.88 | NAA50 (0.51) | NAA50APLNRNTSR1NMUR2NMUR1 | |
| SCHEMBL30608586 | 0.88 | NAA50 (0.51) | NAA50APLNRNTSR1NMUR2NMUR1 | |
| SCHEMBL30608562 | 0.87 | NAA50 (0.49) | NAA50APLNRNTSR1NMUR2NMUR1 | |
| SCHEMBL30853585 | 0.87 | NAA50 (0.48) | NAA50APLNRNTSR1NMUR2NMUR1 | |
| SCHEMBL30608603 | 0.87 | NAA50 (0.51) | NAA50APLNRNTSR1NMUR2NMUR1 | |
| SCHEMBL30608629 | 0.87 | NAA50 (0.51) | NAA50APLNRNTSR1RAMP3CALCR | |
| SCHEMBL31191354 | 0.87 | NAA50 (0.49) | NAA50APLNRNTSR1OPRD1RAMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220227888-A1 | BISPECIFIC BINDING CONSTRUCTS WITH SELECTIVELY CLEAVABLE LINKERS | AMGEN INC. (US) | 2022-07-21 | — | — | US | disclosed |
| EP-3980464-A1 | BISPECIFIC BINDING CONSTRUCTS WITH SELECTIVELY CLEAVABLE LINKERS | Amgen Inc. (US) | 2022-04-13 | — | — | EP | disclosed |
| CN-114269784-A | Bispecific binding constructs with selectively cleavable linkers | 美国安进公司 | 2022-04-01 | — | — | CN | disclosed |