Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL909014 | 1.00 | TDP1 (0.47) | TDP1ATMALDH1A1HIF1ATSHR | |
| SCHEMBL15221112 | 0.81 | TDP1 (0.42) | TDP1ATMALDH1A1HIF1ATSHR | |
| SCHEMBL2258709 | 0.81 | TSHR (0.44) | TDP1ATMALDH1A1HIF1ATSHR | |
| SCHEMBL30072914 | 0.81 | TSHR (0.44) | TDP1ATMALDH1A1HIF1ATSHR | |
| SCHEMBL1749639 | 0.81 | TDP1 (0.44) | TDP1ATMALDH1A1HIF1ATSHR | |
| SCHEMBL31364996 | 0.78 | TDP1 (0.44) | TDP1ATMALDH1A1HIF1ATSHR | |
| SCHEMBL30890730 | 0.78 | CTSB (0.53) | TDP1ATMALDH1A1TSHRCYP3A4 | |
| SCHEMBL9982714 | 0.78 | CTSB (0.53) | TDP1ATMALDH1A1TSHRCYP3A4 | |
| SCHEMBL6990761 | 0.78 | MAPT (0.49) | TDP1ATMALDH1A1HIF1ATSHR | |
| SCHEMBL6837266 | 0.78 | CTSB (0.42) | TDP1ATMALDH1A1HIF1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665456-A1 | BENZIMIDAZOLE AND BENZIMIDAZOLONE BASED PROTAC COMPOUNDS FOR THE TARGETED DEGRADATION OF LEUCINE RICH REPEAT KINASE 2 (LRRK2) | Arvinas Operations, Inc. (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2025109540-A1 | MACROCYCLIC COMPOUNDS AS KIF18A INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2025-05-30 | — | — | WO | disclosed |
| WO-2025096771-A1 | MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-05-08 | — | — | WO | disclosed |
| WO-2025072629-A1 | BENZIMIDAZOLE AND BENZIMIDAZOLONE BASED PROTAC COMPOUNDS FOR THE TARGETED DEGRADATION OF LEUCINE RICH REPEAT KINASE 2 (LRRK2) | ARVINAS OPERATIONS, INC. (US) | 2025-04-03 | — | — | WO | disclosed |
| CN-115703765-B | Substituted triazole derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-112469710-B | Pyridyl and pyrazinyl- (aza) indole sulfonamides | 优时比制药有限公司 | 2024-05-14 | — | — | CN | disclosed |
| EP-4291560-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | Jacobio Pharmaceuticals Co., Ltd. (CN) | 2023-12-20 | — | — | EP | disclosed |
| CN-116848114-A | Tricyclic derivatives useful as PARP7 inhibitors | 北京加科思新药研发有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-116615199-A | Heterocyclic compounds as diacylglycerol kinase inhibitors and uses thereof | 株式会社LG化学 | 2023-08-18 | — | — | CN | disclosed |
| WO-2022170974-A9 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2023-03-30 | — | — | WO | disclosed |
| CN-115703765-A | Substituted triazole derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2023-02-17 | — | — | CN | disclosed |
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |
| CN-113480476-B | 4-fluoropyridine derivative and preparation method and application thereof | 山东师范大学 | 2022-07-22 | — | — | CN | disclosed |
| CN-110734397-B | Synthetic method of 4- (difluoromethyl) -2-hydroxypyridine-5-sulfonyl chloride | 阿里生物新材料（常州）有限公司 | 2022-04-05 | — | — | CN | disclosed |