Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 6/20 | 0.72 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25310955 | 1.00 | TTR (0.72) | TTRALBARHSD17B10GAA | |
| SCHEMBL29433284 | 1.00 | TTR (0.72) | TTRALBARHSD17B10GAA | |
| SCHEMBL26740133 | 0.90 | TTR (0.59) | TTRALBHSD17B10GAASMN1; SMN2 | |
| SCHEMBL15816962 | 0.84 | TTR (1.00) | TTRALBARHSD17B10GAA | |
| SCHEMBL26745347 | 0.81 | TTR (0.79) | TTRALBARHSD17B10GAA | |
| SCHEMBL17522791 | 0.81 | TTR (0.94) | TTRALBARHSD17B10GAA | |
| SCHEMBL25311559 | 0.81 | TTR (0.77) | TTRALBARHSD17B10GAA | |
| SCHEMBL21378627 | 0.77 | TTR (0.81) | TTRALBARSMN1; SMN2MEN1 | |
| SCHEMBL26744380 | 0.77 | TTR (0.65) | TTRALBHSD17B10GAASMN1; SMN2 | |
| SCHEMBL19801746 | 0.76 | TTR (0.84) | TTRALBARHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4214189-A1 | AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS | UCL Business Ltd (GB) | 2023-07-26 | — | — | EP | disclosed |
| WO-2022058733-A1 | AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS | UCL BUSINESS PLC (GB) | 2022-03-24 | — | — | WO | disclosed |