Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 6/20 | 0.94 |
| ▸ | ALB | P02768 | 1/20 | 0.78 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15816962 | 0.97 | TTR (1.00) | TTRALBARHSD17B10MAPT | |
| SCHEMBL15832081 | 0.90 | TTR (0.95) | TTRALBHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL17522783 | 0.89 | TTR (0.81) | TTRALBHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL19801746 | 0.88 | TTR (0.84) | TTRALBARHSD17B10MAPT | |
| Acoramidis SCHEMBL29350324 | 0.88 | TTR (1.00) | TTRALBHSD17B10MAPTSMN1; SMN2 | |
| Acoramidis SCHEMBL15816954 | 0.88 | TTR (1.00) | TTRALBHSD17B10MAPTSMN1; SMN2 | |
| Acoramidis SCHEMBL20475239 | 0.87 | TTR (0.98) | TTRALBHSD17B10MAPTSMN1; SMN2 | |
| Acoramidis SCHEMBL29390976 | 0.87 | TTR (0.98) | TTRALBHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL24953188 | 0.85 | TTR (0.83) | TTRALBHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL26745347 | 0.85 | TTR (0.79) | TTRALBARHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11129902-B2 | Enhanced SN-38 anticancer agent | Alhamadsheh, Mamoun M. (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200384117-A1 | ENHANCED SN-38 ANTICANCER AGENT | MAHA THERAPEUTICS, INC. | 2020-12-10 | — | — | US | disclosed |
| US-10772967-B2 | Enhanced anticancer agent | Alhamadsheh, Mamoun M. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20200179525-A1 | ENHANCED ANTICANCER AGENT | MAHA THERAPEUTICS, INC. | 2020-06-11 | — | — | US | disclosed |
| US-10596269-B2 | Delivering enhanced active agents | Alhamadsheh, Mamoun M. (US) | 2020-03-24 | — | — | US | disclosed |
| US-10363318-B2 | Enhanced active agents | Alhamadsheh, Mamoun M. (US) | 2019-07-30 | — | — | US | disclosed |
| US-20190076546-A1 | ENHANCED ACTIVE AGENTS | MAHA THERAPEUTICS, INC. | 2019-03-14 | — | — | US | disclosed |
| US-10172959-B2 | Systems for stabilizing and delivering active agents | Alhamadsheh, Mamoun M. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180021446-A1 | SYSTEMS FOR STABILIZING AND DELIVERING ACTIVE AGENTS | MAHA THERAPEUTICS, INC. | 2018-01-25 | — | — | US | disclosed |
| US-20180021446-A1 | SYSTEMS FOR STABILIZING AND DELIVERING ACTIVE AGENTS | MAHA THERAPEUTICS, INC. | 2018-01-25 | — | — | US | disclosed |
| US-20160045609-A1 | CONJUGATION OF PHARMACEUTICALLY ACTIVE AGENTS WITH TRANSTHYRETIN LIGANDS THROUGH ADJUSTABLE LINKERS TO INCREASE SERUM HALF-LIFE | MAHA THERAPEUTICS, INC. | 2016-02-18 | — | — | US | disclosed |
| US-20160045609-A1 | CONJUGATION OF PHARMACEUTICALLY ACTIVE AGENTS WITH TRANSTHYRETIN LIGANDS THROUGH ADJUSTABLE LINKERS TO INCREASE SERUM HALF-LIFE | MAHA THERAPEUTICS, INC. | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10172959-B2 | Systems for stabilizing and delivering active agents | SERPINA6, SERPINC1, SERPINE1 | TTR 67/4885ALB 30/4885AR 4026/4885 |
| US-10596269-B2 | Delivering enhanced active agents | SERPINA6, FCGR2A, FCGR1A | TTR 234/4885ALB 93/4885AR 3625/4885 |
| US-20180021446-A1 | SYSTEMS FOR STABILIZING AND DELIVERING ACTIVE AGENTS | SERPINA6, SERPINC1, SERPINE1 | TTR 67/4885ALB 30/4885AR 4026/4885 |
| US-20200384117-A1 | ENHANCED SN-38 ANTICANCER AGENT | LENG8, TSG101, CD47 | TTR 564/4885ALB 72/4885AR 3080/4885 |
| US-20200179525-A1 | ENHANCED ANTICANCER AGENT | SERPINA6, HDGF, SERPINA3 | TTR 527/4885ALB 38/4885AR 2799/4885 |
| US-11129902-B2 | Enhanced SN-38 anticancer agent | LENG8, TSG101, CD47 | TTR 564/4885ALB 72/4885AR 3080/4885 |
| US-10772967-B2 | Enhanced anticancer agent | SERPINA6, HDGF, SERPINA3 | TTR 527/4885ALB 38/4885AR 2799/4885 |
| US-20160045609-A1 | CONJUGATION OF PHARMACEUTICALLY ACTIVE AGENTS WITH TRANSTHYRETIN LIGANDS THROUGH ADJUSTABLE LINKERS TO INCREASE SERUM HALF-LIFE | TTR, TTPA, SERPINA6 | TTR 1/4885ALB 4/4885AR 3715/4885 |
| US-10363318-B2 | Enhanced active agents | SERPINA6, SERPINB1, SERPINA3 | TTR 266/4885ALB 92/4885AR 4226/4885 |
| US-20190076546-A1 | ENHANCED ACTIVE AGENTS | SERPINA6, SERPINB1, SERPINA3 | TTR 266/4885ALB 92/4885AR 4226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.