Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 11/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.39 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21294511 | 1.00 | ACSS2 (0.58) | ACSS2HTTLMNAPKMMAPT | |
| SCHEMBL21294436 | 0.84 | ACSS2 (0.63) | ACSS2HTTLMNAPKMMAPT | |
| SCHEMBL21294476 | 0.79 | ACSS2 (0.67) | ACSS2HTTLMNAPKMMAPT | |
| SCHEMBL21294461 | 0.79 | ACSS2 (0.62) | ACSS2HTTLMNAPKMMAPT | |
| SCHEMBL21294539 | 0.78 | ACSS2 (0.71) | ACSS2HTTLMNAPKMMAPT | |
| SCHEMBL21305610 | 0.78 | ACSS2 (0.57) | ACSS2HTTLMNAPKMMAPT | |
| SCHEMBL29433528 | 0.77 | ACSS2 (0.72) | ACSS2HTTLMNAPKMMAPT | |
| SCHEMBL21294535 | 0.77 | ACSS2 (0.72) | ACSS2HTTLMNAPKMMAPT | |
| SCHEMBL21305661 | 0.76 | ACSS2 (0.69) | ACSS2HTTLMNAPKMMAPT | |
| SCHEMBL21294452 | 0.76 | ACSS2 (0.71) | ACSS2HTTLMNAPKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114008025-A | ACSS2 inhibitors and methods of use thereof | 美特波米德有限公司 | 2022-02-01 | — | — | CN | disclosed |