Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CCR4 | P51679 | 2/20 | 0.43 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | EDNRB | P24530 | 2/20 | 0.41 |
| ▸ | EDNRA | P25101 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22980484 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2GAAMAPK1KMT2ACA12 | |
| SCHEMBL29434792 | 0.87 | HSD11B1 (0.45) | SMN1; SMN2GAAMAPK1KMT2ACA12 | |
| SCHEMBL29434879 | 0.87 | HSD11B1 (0.45) | SMN1; SMN2CCR4PTGES2HSD11B1EDNRB | |
| SCHEMBL22980330 | 0.87 | HSD11B1 (0.45) | SMN1; SMN2GAAMAPK1KMT2ACA12 | |
| SCHEMBL22980410 | 0.87 | HSD11B1 (0.45) | SMN1; SMN2CCR4PTGES2HSD11B1EDNRB | |
| SCHEMBL22980994 | 0.87 | HSD11B1 (0.47) | SMN1; SMN2CCR4PTGES2HSD11B1EDNRB | |
| SCHEMBL29666141 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAMAPK1KMT2ACA12 | |
| SCHEMBL22980912 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAMAPK1KMT2ACA12 | |
| SCHEMBL24467922 | 0.82 | HSD11B1 (0.47) | CCR4PTGES2HSD11B1EDNRBEDNRA | |
| SCHEMBL24467921 | 0.80 | EDNRA (0.49) | CCR4PTGES2HSD11B1EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4013495-A1 | ARYLSULFONAMIDE DERIVATIVES AS MGLUR4 NEGATIVE ALLOSTERIC MODULATORS | F. Hoffmann-La Roche AG (CH) | 2022-06-22 | — | — | EP | claimed |
| CN-114174266-A | Arylsulfonamide derivatives as MGLUR4 negative allosteric modulators | 豪夫迈·罗氏有限公司 | 2022-03-11 | — | — | CN | claimed |
| EP-4013495-A1 | ARYLSULFONAMIDE DERIVATIVES AS MGLUR4 NEGATIVE ALLOSTERIC MODULATORS | F. Hoffmann-La Roche AG (CH) | 2022-06-22 | — | — | EP | disclosed |
| CN-114174266-A | Arylsulfonamide derivatives as MGLUR4 negative allosteric modulators | 豪夫迈·罗氏有限公司 | 2022-03-11 | — | — | CN | disclosed |