Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.48 |
| ▸ | PDE9A | O76083 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31540092 | 0.85 | HRH1 (0.43) | EPHX2IKBKBHRH1 | |
| SCHEMBL20400026 | 0.85 | HRH1 (0.43) | EPHX2IKBKBHRH1 | |
| SCHEMBL28179921 | 0.81 | CYP19A1 (0.44) | LRRK2EPHX2IKBKBHRH1 | |
| SCHEMBL77615 | 0.81 | PARP10 (0.48) | LRRK2EPHX2IKBKBHRH1 | |
| SCHEMBL19717281 | 0.79 | HTR2A (0.37) | LRRK2PDE9APDE1AEPHX2IKBKB | |
| SCHEMBL13165443 | 0.79 | CYP19A1 (0.46) | LRRK2EPHX2HRH1 | |
| SCHEMBL16708022 | 0.79 | HRH1 (0.59) | PDE9ADHFRSYKKAT2BBAZ2B | |
| SCHEMBL23753940 | 0.78 | CHRNB2 (0.58) | LRRK2PDE9AEPHX2 | |
| SCHEMBL30471930 | 0.78 | CHRNB2 (0.58) | LRRK2PDE9AEPHX2 | |
| SCHEMBL3116000 | 0.78 | EPHX2 (0.39) | EPHX2IKBKBHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3959207-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2022-03-02 | — | — | EP | disclosed |