Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114414 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| Ammonia Solution, Strong SCHEMBL2082802 | 0.98 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL21810899 | 0.98 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL19814625 | 0.98 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL1921572 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL15353020 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL10442032 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL27615166 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL6348517 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 | |
| SCHEMBL29080 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4461733-A1 | 1-AMINOBENZO[4,5]IMIDAZO[1,2-A]PYRAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION THEREFOR AND USE THEREOF | Sun Yat-Sen University (CN) | 2024-11-13 | — | — | EP | claimed |
| CN-114276354-A | 1-aminobenzo [4,5] imidazo [1,2-a ] pyrazine-3-formamide compound and preparation and application thereof | 中山大学 | 2022-04-05 | — | — | CN | claimed |
| US-20250092050-A1 | 1-AMINOBENZO[4,5]IMIDAZO[1,2-A]PYRAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION THEREFOR AND USE THEREOF | SUN YAT-SEN UNIVERSITY (CN) | 2025-03-20 | — | — | US | disclosed |
| EP-4461733-A1 | 1-AMINOBENZO[4,5]IMIDAZO[1,2-A]PYRAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION THEREFOR AND USE THEREOF | Sun Yat-Sen University (CN) | 2024-11-13 | — | — | EP | disclosed |
| CN-113072551-B | Nitrogen-containing biphenyl derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-08-13 | — | — | CN | disclosed |
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | CYTOKINETICS, INC. | 2024-02-29 | — | — | US | disclosed |
| CN-117529476-A | Preparation of substituted 1, 2-diamino heterocyclic derivatives and their use as medicaments | 亚飞络思制药公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-114276354-B | 1-aminobenzo [4,5] imidazo [1,2-a ] pyrazine-3-carboxamide compound, preparation and application thereof | 中山大学 | 2023-06-02 | — | — | CN | disclosed |
| CN-114585625-A | Triazolopyrimidines as A2A/A2B inhibitors | 因赛特公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-114276354-A | 1-aminobenzo [4,5] imidazo [1,2-a ] pyrazine-3-formamide compound and preparation and application thereof | 中山大学 | 2022-04-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250092050-A1 | 1-AMINOBENZO[4,5]IMIDAZO[1,2-A]PYRAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION THEREFOR AND USE THEREOF | ADORA1, ADORA2A, ADORA2B | SMN1; SMN2 4753/4885L3MBTL1 4260/4885NOS3 1580/4885 |
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | NAMPT, NNT, NAPRT | SMN1; SMN2 2574/4885L3MBTL1 3352/4885NOS3 1192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.