Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 6/20 | 0.50 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.50 |
| ▸ | SGK1 | O00141 | 1/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13306699 | 1.00 | AXL (0.50) | AXLNEK1SGK1CAMKK2BRD4 | |
| SCHEMBL29438406 | 1.00 | AXL (0.50) | AXLNEK1SGK1CAMKK2BRD4 | |
| SCHEMBL2181151 | 0.86 | BTK (0.45) | AXLNEK1SGK1CAMKK2BRD4 | |
| SCHEMBL31403510 | 0.83 | AXL (0.48) | AXLNEK1SGK1CAMKK2MAP2K1 | |
| SCHEMBL20292915 | 0.83 | AXL (0.48) | AXLNEK1SGK1CAMKK2BRD4 | |
| SCHEMBL20780050 | 0.82 | AXL (0.47) | AXLNEK1SGK1CAMKK2MAP2K1 | |
| SCHEMBL30504208 | 0.82 | AXL (0.47) | AXLNEK1SGK1CAMKK2MAP2K1 | |
| SCHEMBL19208834 | 0.79 | MAPK1 (0.41) | AXLNEK1SGK1CAMKK2MAPK1 | |
| SCHEMBL29900909 | 0.79 | MAPK1 (0.41) | AXLNEK1SGK1CAMKK2MAPK1 | |
| SCHEMBL22578339 | 0.78 | MTNR1A (0.46) | AXLNEK1SGK1CAMKK2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022051569-A1 | SUBSTITUTED 3-PIPERIDINYL-PYRROLO[2,3-B]PYRIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Ikena Oncology, Inc. (US) | 2022-03-10 | — | — | WO | disclosed |