Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.46 |
| ▸ | YAP1 | P46937 | 1/20 | 0.46 |
| ▸ | BMP1 | P13497 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718095 | 1.00 | TEAD1 (0.46) | TEAD1YAP1BMP1TAS2R14LMNA | |
| SCHEMBL29438894 | 0.92 | TEAD1 (0.47) | TEAD1YAP1BMP1LMNASMN1; SMN2 | |
| SCHEMBL22718289 | 0.92 | TEAD1 (0.47) | TEAD1YAP1BMP1LMNASMN1; SMN2 | |
| SCHEMBL22717994 | 0.89 | TEAD1 (0.48) | TEAD1YAP1BMP1TAS2R14LMNA | |
| SCHEMBL29438911 | 0.89 | TEAD1 (0.48) | TEAD1YAP1BMP1TAS2R14LMNA | |
| SCHEMBL22843441 | 0.86 | TEAD1 (0.51) | TEAD1YAP1TAS2R14LMNASMN1; SMN2 | |
| SCHEMBL22718145 | 0.83 | BMP1 (0.38) | TEAD1YAP1BMP1KDM4EKDR | |
| SCHEMBL29438915 | 0.81 | TEAD1 (0.49) | TEAD1YAP1BMP1LMNASMN1; SMN2 | |
| SCHEMBL22718251 | 0.81 | TEAD1 (0.49) | TEAD1YAP1BMP1LMNASMN1; SMN2 | |
| SCHEMBL29438917 | 0.81 | TEAD1 (0.49) | TEAD1YAP1BMP1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |