Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.51 |
| ▸ | YAP1 | P46937 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718146 | 1.00 | TEAD1 (0.51) | TEAD1YAP1MEN1KMT2AKAT8 | |
| SCHEMBL22718104 | 0.87 | TEAD1 (0.49) | TEAD1YAP1MEN1KMT2AKAT8 | |
| SCHEMBL29438921 | 0.87 | TEAD1 (0.49) | TEAD1YAP1MEN1KMT2AKAT8 | |
| SCHEMBL29438846 | 0.87 | TEAD1 (0.45) | TEAD1YAP1MEN1KMT2AKAT8 | |
| SCHEMBL22718180 | 0.87 | TEAD1 (0.45) | TEAD1YAP1MEN1KMT2AKAT8 | |
| SCHEMBL22718031 | 0.86 | TEAD1 (0.44) | TEAD1YAP1MEN1KMT2AKAT8 | |
| SCHEMBL29438837 | 0.86 | TEAD1 (0.44) | TEAD1YAP1MEN1KMT2AKAT8 | |
| SCHEMBL22718251 | 0.86 | TEAD1 (0.49) | TEAD1YAP1MEN1KMT2AKAT8 | |
| SCHEMBL29438915 | 0.86 | TEAD1 (0.49) | TEAD1YAP1MEN1KMT2AKAT8 | |
| SCHEMBL29438917 | 0.86 | TEAD1 (0.49) | TEAD1YAP1MEN1KMT2AKAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |