Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.50 |
| ▸ | TEAD1 | P28347 | 4/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | IDH2 | P48735 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21054312 | 1.00 | MPO (0.50) | MPOTEAD1AKR1C3AKR1C2IDH2 | |
| SCHEMBL21054150 | 0.88 | TEAD1 (0.40) | MPOTEAD1AKR1C3AKR1C2 | |
| SCHEMBL22719726 | 0.84 | MAPT (0.44) | MPOTEAD1AKR1C3AKR1C2IDH2 | |
| SCHEMBL30061296 | 0.84 | AKR1C3 (0.53) | MPOAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL31332060 | 0.84 | AKR1C3 (0.41) | MPOTEAD1AKR1C3AKR1C2IDH2 | |
| SCHEMBL22718300 | 0.84 | AKR1C3 (0.41) | MPOTEAD1AKR1C3AKR1C2IDH2 | |
| SCHEMBL21054916 | 0.84 | AKR1C3 (0.53) | MPOAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL21090762 | 0.83 | DDR2 (0.48) | MPOAKR1C3AKR1C2ALDH1A1GAA | |
| SCHEMBL21054684 | 0.83 | AKR1C3 (0.47) | MPOAKR1C3AKR1C2MAPT | |
| SCHEMBL21054301 | 0.83 | AKR1C3 (0.47) | MPOAKR1C3AKR1C2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| CN-114466839-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2022-05-10 | — | — | CN | disclosed |
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |
| EP-3976192-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |