Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.59 |
| ▸ | YAP1 | P46937 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718028 | 1.00 | TEAD1 (0.59) | TEAD1YAP1MAPTTNNI3KBRAF | |
| SCHEMBL20766513 | 0.85 | TEAD1 (0.80) | TEAD1YAP1MAPTTNNI3KBRAF | |
| SCHEMBL22843433 | 0.84 | MAPT (0.47) | TEAD1YAP1MAPTKDM4EMEN1 | |
| SCHEMBL24788984 | 0.81 | TEAD1 (0.55) | TEAD1YAP1TNNI3KBRAFBRD4 | |
| SCHEMBL29438843 | 0.79 | KDR (0.43) | TEAD1YAP1MAPTKDM4EMEN1 | |
| SCHEMBL22718120 | 0.79 | KDR (0.43) | TEAD1YAP1MAPTKDM4EMEN1 | |
| SCHEMBL24496032 | 0.79 | TEAD1 (0.59) | TEAD1YAP1MAPTTNNI3KBRD4 | |
| SCHEMBL24496110 | 0.78 | TEAD1 (0.58) | TEAD1YAP1MAPTTNNI3KBRD4 | |
| SCHEMBL29648323 | 0.78 | TEAD1 (0.58) | TEAD1YAP1MAPTTNNI3KBRD4 | |
| SCHEMBL24501949 | 0.78 | TEAD1 (0.49) | TEAD1YAP1TNNI3KBRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |