Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.58 |
| ▸ | YAP1 | P46937 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.36 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.36 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.36 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.36 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.36 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.36 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.36 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496110 | 1.00 | TEAD1 (0.58) | TEAD1YAP1TSHRL3MBTL1PDE2A | |
| SCHEMBL22718228 | 0.87 | TEAD1 (0.43) | TEAD1YAP1MAPTEGFRATP1A1 | |
| SCHEMBL22718231 | 0.87 | TEAD1 (0.43) | TEAD1YAP1MAPTEGFRATP1A1 | |
| SCHEMBL22718246 | 0.87 | TEAD1 (0.43) | TEAD1YAP1MAPTEGFRATP1A1 | |
| SCHEMBL22718168 | 0.86 | TEAD1 (0.72) | TEAD1YAP1TSHRL3MBTL1PDE2A | |
| SCHEMBL29438844 | 0.86 | TEAD1 (0.72) | TEAD1YAP1TSHRL3MBTL1PDE2A | |
| SCHEMBL22718346 | 0.86 | TEAD1 (0.72) | TEAD1YAP1TSHRL3MBTL1PDE2A | |
| SCHEMBL22718170 | 0.86 | TEAD1 (0.72) | TEAD1YAP1TSHRL3MBTL1PDE2A | |
| SCHEMBL29438888 | 0.86 | TEAD1 (0.72) | TEAD1YAP1TSHRL3MBTL1PDE2A | |
| SCHEMBL24496032 | 0.82 | TEAD1 (0.59) | TEAD1YAP1TSHRL3MBTL1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |