Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.58 |
| ▸ | CYP2E1 | P05181 | 7/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.58 |
| ▸ | CYP2C8 | P10632 | 7/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.58 |
| ▸ | CYP2B6 | P20813 | 7/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371528 | 1.00 | KDM4E (0.61) | KDM4EHSD17B10LMNAALDH1A1NPC1 | |
| SCHEMBL12909159 | 0.86 | NPC1 (0.54) | KDM4EHSD17B10LMNAALDH1A1NPC1 | |
| SCHEMBL30572581 | 0.86 | NPC1 (0.54) | KDM4EHSD17B10LMNAALDH1A1NPC1 | |
| SCHEMBL21905237 | 0.86 | NPC1 (0.54) | KDM4EHSD17B10LMNAALDH1A1NPC1 | |
| SCHEMBL1286065 | 0.85 | KDM4E (0.57) | KDM4EHSD17B10LMNAALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL31587365 | 0.84 | KDM4E (0.55) | KDM4EHSD17B10LMNAALDH1A1NPC1 | |
| SCHEMBL30572566 | 0.81 | DHODH (0.61) | KDM4EHSD17B10LMNAALDH1A1NPC1 | |
| SCHEMBL21905344 | 0.81 | DHODH (0.61) | KDM4EHSD17B10LMNAALDH1A1NPC1 | |
| SCHEMBL12909170 | 0.81 | ALDH1A1 (0.62) | KDM4EHSD17B10LMNAALDH1A1NPC1 | |
| SCHEMBL16307902 | 0.80 | CBFB (0.52) | KDM4EHSD17B10LMNAALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220064150-A1 | SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS | PTC THERAPEUTICS INC (US) | 2022-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220064150-A1 | SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS | BMI1, BRPF3, BAZ2A | KDM4E 155/4885HSD17B10 3474/4885LMNA 3348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.