Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 8/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22715380 | 1.00 | EGFR (0.43) | EGFRMKNK2MAP4K4PIK3CDPIK3R2 | |
| SCHEMBL1724431 | 0.79 | EGFR (0.45) | EGFRMKNK2MAP4K4PIK3CDPIK3R2 | |
| SCHEMBL22648545 | 0.79 | CCR1 (0.46) | MAP4K4 | |
| SCHEMBL29439690 | 0.76 | EGFR (0.43) | EGFRMKNK2MAP4K4 | |
| SCHEMBL1034679 | 0.76 | EGFR (0.43) | EGFRMKNK2MAP4K4 | |
| SCHEMBL23000191 | 0.76 | EGFR (0.43) | EGFRMKNK2MAP4K4PIK3CDPIK3R2 | |
| SCHEMBL29439641 | 0.76 | MAP4K4 (0.54) | MAP4K4 | |
| SCHEMBL15587364 | 0.76 | MAP4K4 (0.54) | MAP4K4 | |
| SCHEMBL24121650 | 0.76 | MAP4K4 (0.38) | MAP4K4 | |
| SCHEMBL22716398 | 0.76 | EGFR (0.40) | EGFRMKNK2MAP4K4PIK3CDPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119546602-A | Pyrrolidone derivatives as inhibitors of nfkb-induced kinase | 詹森药业有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-118908957-A | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114222737-B | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-3976597-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | Janssen Pharmaceutica NV (BE) | 2022-04-06 | — | — | EP | disclosed |
| CN-114222737-A | Small molecule inhibitor of NF-kB induced kinase | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |