Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29440077 | 1.00 | HTR2C (0.51) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL26009502 | 0.83 | HTR2C (0.59) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL1012764 | 0.83 | HTR2C (0.52) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL9546447 | 0.77 | HTR2C (0.57) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL26010039 | 0.77 | HTR2C (0.44) | HTR2CSMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL29440145 | 0.77 | HTR2C (0.57) | HTR2CSMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL30800897 | 0.77 | HTR2C (0.57) | HTR2CSMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL25635682 | 0.77 | HTR2C (0.57) | HTR2CSMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL29012379 | 0.77 | HTR2C (0.57) | HTR2CSMN1; SMN2NPC1RAB9APSEN1 | |
| SCHEMBL29440040 | 0.77 | HTR2C (0.48) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4199925-A1 | CYCLOPENTAPYRROLE OREXIN RECEPTOR AGONISTS | Merck Sharp & Dohme LLC (US) | 2023-06-28 | — | — | EP | disclosed |
| WO-2022040058-A1 | CYCLOPENTAPYRROLE OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-02-24 | — | — | WO | disclosed |