Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2944325 | 0.70 | GAA (0.32) | — | |
| SCHEMBL2944324 | 0.68 | ALDH1A1 (0.32) | — | |
| SCHEMBL2062292 | 0.67 | ALDH1A1 (0.37) | SMN1; SMN2 | |
| SCHEMBL2062766 | 0.62 | ALDH1A1 (0.36) | SMN1; SMN2 | |
| SCHEMBL2943806 | 0.59 | ALDH1A1 (0.37) | SMN1; SMN2 | |
| SCHEMBL2913929 | 0.56 | CRBN (0.37) | — | |
| SCHEMBL17605160 | 0.56 | ALDH1A1 (0.61) | — | |
| SCHEMBL2062829 | 0.55 | ALK (0.40) | SMN1; SMN2 | |
| SCHEMBL19182458 | 0.55 | CHEK1 (0.41) | SMN1; SMN2 | |
| SCHEMBL19756312 | 0.55 | ALDH1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |