Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.55 |
| ▸ | BCR | P11274 | 8/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.55 |
| ▸ | PRKCA | P17252 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 4/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945813 | 0.87 | ABL1 (0.58) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL2938869 | 0.85 | ABL1 (0.55) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL2945044 | 0.83 | ABL1 (0.61) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL2947554 | 0.79 | PRKCA (0.45) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL2946486 | 0.78 | ABL1 (0.59) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL2944346 | 0.76 | ABL1 (0.57) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL4899644 | 0.75 | ABL1 (0.63) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL2939690 | 0.74 | ABL1 (0.60) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL2945911 | 0.74 | ABL1 (0.68) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL2938799 | 0.73 | ABL1 (0.60) | ABL1PDGFRABCRPDGFRBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635835-B1 | 2-AMINOPYRIMIDINE DERIVATIVES AS RAF KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-01-06 | — | — | EP | claimed |