Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | HCK | P08631 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1054325 | 1.00 | SLC6A2 (0.37) | SLC6A2SLC6A4UHRF1MAPTALDH1A1 | |
| SCHEMBL25955725 | 0.81 | UHRF1 (0.42) | SLC6A2SLC6A4UHRF1MAPTSLC6A3 | |
| SCHEMBL15141866 | 0.80 | AXL (0.42) | SLC6A2SLC6A4UHRF1MAPTALDH1A1 | |
| SCHEMBL24046844 | 0.79 | SLC6A2 (0.42) | SLC6A2SLC6A4ALDH1A1TSHRKDM4E | |
| SCHEMBL15980355 | 0.78 | HTR2A (0.39) | MAPTALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL103648 | 0.75 | PTPN1 (0.33) | SLC6A2SLC6A4SLC6A3XDH | |
| SCHEMBL1800081 | 0.74 | EGFR (0.32) | EGFRXDH | |
| SCHEMBL26906152 | 0.74 | HDAC3 (0.36) | SLC6A2SLC6A4UHRF1 | |
| SCHEMBL15980810 | 0.73 | L3MBTL1 (0.40) | MAPTALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL15978366 | 0.73 | SMN1; SMN2 (0.40) | MAPTALDH1A1KMT2AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057759-B | Fused tetracyclic derivative, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-114057759-A | Condensed tetracyclic derivative, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-02-18 | — | — | CN | disclosed |