Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28712194 | 1.00 | TLR8 (0.45) | TLR8TLR7TLR9PDE4BDDB1 | |
| SCHEMBL19761062 | 0.85 | TLR8 (0.51) | TLR8TLR7TLR9PDE4BDDB1 | |
| SCHEMBL29555763 | 0.85 | TLR8 (0.51) | TLR8TLR7TLR9PDE4BDDB1 | |
| SCHEMBL28705456 | 0.83 | TLR8 (0.51) | TLR8TLR7TLR9 | |
| SCHEMBL29444448 | 0.83 | TLR8 (0.51) | TLR8TLR7TLR9 | |
| SCHEMBL28709798 | 0.83 | MAPT (0.47) | TLR8TLR7TLR9PDE4BDDB1 | |
| SCHEMBL29444440 | 0.83 | MAPT (0.47) | TLR8TLR7TLR9PDE4BDDB1 | |
| SCHEMBL19838731 | 0.79 | PDE4B (0.46) | TLR8TLR7TLR9PDE4BDDB1 | |
| SCHEMBL29555376 | 0.79 | PDE4B (0.46) | TLR8TLR7TLR9PDE4BDDB1 | |
| SCHEMBL29444446 | 0.79 | GABRP (0.45) | PDE4BNAMPTCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057759-A | Condensed tetracyclic derivative, preparation method and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-02-18 | — | — | CN | disclosed |