Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 18/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19211076 | 1.00 | DDR1 (0.59) | DDR1PPARGNR2E3NCOR2OPRL1 | |
| SCHEMBL19235349 | 0.86 | DDR1 (0.62) | DDR1PPARGNR2E3NCOR2 | |
| SCHEMBL19235257 | 0.86 | DDR1 (0.62) | DDR1PPARGNR2E3NCOR2 | |
| SCHEMBL31414312 | 0.86 | DDR1 (0.56) | DDR1PPARGNR2E3NCOR2OPRL1 | |
| SCHEMBL19210996 | 0.85 | DDR1 (0.62) | DDR1PPARGNR2E3NCOR2 | |
| SCHEMBL19235258 | 0.85 | DDR1 (0.62) | DDR1PPARGNR2E3NCOR2 | |
| SCHEMBL19211044 | 0.85 | DDR1 (0.61) | DDR1DDR2 | |
| SCHEMBL19235203 | 0.85 | DDR1 (0.60) | DDR1DDR2 | |
| SCHEMBL23234210 | 0.85 | DDR1 (0.64) | DDR1PPARGNR2E3NCOR2OPRL1 | |
| SCHEMBL20783237 | 0.84 | DDR1 (0.61) | DDR1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884096-B | Spiroindolinones as DDR1 inhibitors | 豪夫迈·罗氏有限公司 | 2022-03-22 | — | — | CN | disclosed |