Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.46 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 2/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28265746 | 0.94 | — | — | |
| Bicarbonate SCHEMBL28898421 | 0.94 | — | — | |
| Bicarbonate SCHEMBL15546320 | 0.93 | CA1 (0.83) | CA1CA2CA9TSHREGLN1 | |
| Bicarbonate SCHEMBL25390 | 0.93 | — | — | |
| Bicarbonate SCHEMBL4760181 | 0.93 | CA1 (0.83) | CA1CA2CA9TSHREGLN1 | |
| Bicarbonate SCHEMBL5304565 | 0.93 | CA1 (0.83) | CA1CA2CA9TSHREGLN1 | |
| Bicarbonate SCHEMBL11678451 | 0.93 | CA1 (0.83) | CA1CA2CA9TSHREGLN1 | |
| Bicarbonate SCHEMBL360784 | 0.93 | CA1 (0.83) | CA1CA2CA9TSHREGLN1 | |
| Bicarbonate SCHEMBL10353161 | 0.93 | CA1 (0.83) | CA1CA2CA9TSHREGLN1 | |
| Bicarbonate SCHEMBL17309693 | 0.93 | CA1 (0.83) | CA1CA2CA9TSHREGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458881-B | Carotenoid derivatives, its pharmaceutically acceptable salt or its pharmaceutically acceptable esters or amides | 阿斯塔制药有限公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-109476569-A | The manufacturing method of Guerbet alcohol | 花王株式会社 | 2019-03-15 | — | — | CN | disclosed |
| CN-105829324-B | The 5,5- bicyclic heterocycles for killing harmful organism activity and being substituted with sulfur-bearing substituent group | 先正达参股股份有限公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-106132939-B | Process for producing tetrazolinone compound | 住友化学株式会社 | 2018-11-13 | — | — | CN | disclosed |
| CN-108409678-A | The manufacturing method of Terazololine-one compound | 住友化学株式会社 | 2018-08-17 | — | — | CN | disclosed |
| CN-108368194-A | （Methyl）The manufacturing method of acryloyl group end polyisobutene based polymer | 株式会社钟化 | 2018-08-03 | — | — | CN | disclosed |
| CN-106458881-A | Carotenoid derivative, pharmaceutically acceptable salt thereof, and pharmaceutically acceptable ester or amide thereof | 富士化学工业株式会社 | 2017-02-22 | — | — | CN | disclosed |
| CN-106132939-A | Process for producing tetrazolinone compound | 住友化学株式会社 | 2016-11-16 | — | — | CN | disclosed |
| CN-105829324-A | PESTICIDALLY ACTIVE SUBSTITUTED 5, 5-BICYCLIC HETEROCYCLES WITH SULPHUR CONTAINING SUBSTITUENTS | 先正达参股股份有限公司 | 2016-08-03 | — | — | CN | disclosed |
| EP-1693358-B1 | PROCESS FOR PRODUCING EPOXYTRIAZOLE COMPOUND AND INTERMEDIATE THEREFOR | SUMITOMO CHEMICAL CO (JP) | 2010-09-08 | — | — | EP | disclosed |
| EP-1693358-A1 | PROCESS FOR PRODUCING EPOXYTRIAZOLE COMPOUND AND INTERMEDIATE THEREFOR | SUMITOMO CHEMICAL CO., LTD. (JP) | 2006-08-23 | — | — | EP | disclosed |